Center for High-Throughput Functional Annotation of Natural Products
Center Overview

Determination of the mechanism of action to botanicals and natural products (mixtures and pure compounds) is often rate limiting for the safe and efficacious use as supplements and therapeutics. Botanicals and dietary supplements are particularly difficult, as these are often complex mixtures that can change in the constituents and concentration of individual compounds. The rapidly growing botanical dietary supplement industry faces a number of challenges regarding the quality, safety and benefit of these products. In order to address these issues, rigorous and sustained efforts are needed to chemically and biologically characterize these products.

The Center will take advantage of technology platforms developed at the University of Texas Southwestern Medical Center and the University of California, Santa Cruz to study the mechanism of action of botanicals and natural products. The end goal is to provide a series of data-driven websites where the scientific community can probe the function of natural product and botanicals.

A major goal of this Center is to make the technology platform available to the botanical and natural product community. Use the collaboration link to find out how to initiate a collaboration with the center. We also want this website to be a valuable resource for the botanical and natural product community. As such, we will provide information directly and through links with other resources, such as the other CANPIT funded research at the University of Illinois Chicago.

Citological Profiling
Project #1
Cytological profiling and unbiased metabolomics
Project #2
Functional Signature Ontology (FuSiOn) profiling
Bioinformatic Integration
Project #3
Bioinformatic integration of technology platforms

UT Southwestern Medical CenterSimon Fraser UniversityUniversity of California, Santa Cruz