Center for High-Throughput Functional Annotation of Natural Products
Publications

Technology

Potts, M.B.; Kim, Y.; Fisher, K. W.; Hu, Y.; Carrasco, Y.; Ou, Y-H.; Herrera, M.; Cubillos, F.; Xiao, G.; Hofree, M.; Ideker, T.; Xie, Y.; Lewis, R. E.; MacMillan, J. B.*; White, M. A.* "Broad-scale mode-of-action annotation of natural product perturbations by functional signature ontology (FUSION)" Science Signaling 2013, 6, ra90. (http://stke.sciencemag.org/content/6/297/ra90)

Schulze, C. J.; Bray, W. M., Woerhmann; M. H., Stuart, J.; Lokey, R. S.; and Linington, R. G. "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening" Chem. Biol. 2013, 20, 285. (http://www.sciencedirect.com/science/article/pii/S1074552112004887)

Woehrmann, M. H;, Bray, W. M.; Durbin, J. K.; Nisam, S. C.; Michael, A. K.; Glassey, E;, Stuart, J. M.; and Lokey, R. S. "Large-scale cytological profiling for functional analysis of bioactive compounds" Mol Biosyst 2013, 9, 2604. (http://pubs.rsc.org/en/Content/ArticleLanding/2013/MB/c3mb70245f)

Ochoa, J. L.; Bray, W. M.; Lokey, R. S.; and Linington, R. G. "Phenotype-Guided Natural Products Discovery Using Cytological Profiling" J. Nat. Prod.2015, 78, 2242. (http://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.5b00455)

Kurita, K. L.; Glassey, E.; Linington, R. G.* "Integration of High-Content Screening and Untargeted Metabolomics for Comprehensive Functional Annotation of Natural Product Libraries." Proceedings of the National Academy of Sciences, USA, 2015, 112, 11999-12004.http://www.pnas.org/content/112/39/11999.long

Applications

Potts, M.A., Rosales, T. I.; McMillan, E. A.; Kim, H.; Ou, Y.; Toombs, J. E.; Brekken, R. A.; MacMillan, J. B.; White, M.A. "Exceptional responders to didemnin B illuminate mechanism of action and pharmacogenomic biomarkers for antineoplastic activity" Nat. Chem. Biol. 2015, 11, 401-408. (http://www.nature.com/nchembio/journal/v11/n6/full/nchembio.1797.html)

Hu, Y.; Potts, M. A.; Herrera, M.; White, M. A.; MacMillan, J. B. "Discoipyrroles A-D, Migration Inhibitors from a marine-derived Bacillus hunanensis" J. Am. Chem. Soc. 2013, 135, 13387−13392. (http://pubs.acs.org/doi/abs/10.1021/ja403412y)

Fisher, K. S.; Das, B.; Kim, H. S.; Clymer, B. K.; Gehring, D.; Smith, D.; Costanzo-Garvey, D.; Fernandez, M.; Brattain, M. G.; Kelly, D.; MacMillan, J. B.; White, M. A.; Lewis, R. E. "AMPK promotes aberrant PGC1β expression to support human colon tumor cell survival" MCB, 2015 (http://mcb.asm.org/content/early/2015/09/01/MCB.00528-15.abstract)


UT Southwestern Medical CenterSimon Fraser UniversityUniversity of California, Santa Cruz